If you experience any of the following serious side effects, contact your doctor immediately or seek emergency medical attention: An allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue or face, hives); swelling of the arms or legs (especially ankles); frequent or persistent erections, or breast tenderness or enlargement (male patients) or voice changes (hoarseness, deepening), hair loss, facial hair growth, clitoral enlargement, or menstrual irregularities (female patients). Effective Dose: Men 100-600 mg/ 25-50 mg/week.
In January 2004, Major League Baseball announced a new drug policy which included random, offseason testing and 10-day suspensions for first-time offenders, 30-days for second-time offenders, 60-days for third-time offenders, and one year for fourth-time offenders, all without pay, in an effort to curtail performance-enhancing drug use (PED) in professional baseball. This policy strengthened baseball's pre-existing ban on controlled substances , including steroids, which has been in effect since 1991.  The policy was to be reviewed in 2008, but under pressure from the . Congress , on November 15, 2005, players and owners agreed to tougher penalties; a 50-game suspension for a first offense, a 100-game suspension for a second, and a lifetime ban for a third.
Skin necrosis is a rare but serious side effect of warfarin. It occurs mainly in obese, female patients, usually within 3 to 10 days of starting therapy, and is associated with the use of high induction doses. Patients with protein C or protein S deficiency are at particular risk. Initially, the lesions consist of painful, indurated, reddened areas, which progress through a stage of blood-filled blisters into well-demarcated blackened necrotic patches. Areas of skin with underlying fatty tissue, such as breasts, flanks and buttocks are most often affected. Pain in a particular area of skin is a premonitory symptom, and withdrawal of the oral anticoagulant at this stage, reversal of its effects with vitamin k or fresh frozen plasma, and the use of heparin may limit the extent of tissue damage.