Secosteroid function

Structural relationship of vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol) with their respective provitamins, cholesterol, and a classic steroid hormone, cortisol (see inset box). The two structural representations presented at the bottom for both vitamin D 3 and vitamin D .2 are equivalent; these are simply different ways of drawing the same molecule. It is to be emphasized that vitamin D 3 is the naturally occurring form of the vitamin; it is produced from 7-dehydrocholesterol, which is present in the skin, by the action of sunlight (see Figure 2). Vitamin D 2 (which is equivalently potent to vitamin D 3 in humans and many mammals, but not birds) is produced commercially by the irradiation of the plant sterol ergosterol with ultraviolet light.

Approximately 50% of . citizens are Vitamin D deficient. The numbers are higher among hispanic and black populations.  The melanin in darker-skinned people interferes with the synthesis of the vitamin D that starts at the level of the skin when the sun comes into contact with it. Therefore, darker-skinned people tend to be more deficient.  Vitamin D is crucial for good health , and may be one of the simplest solutions to a wide range of health problems, from diseases of the eyes to the bowels, and conditions rooted in chronic inflammation and immune dysfunction in particular. It is a common deficiency worldwide, even in sundrenched areas, yet many people, including physicians, are unaware they may be lacking this important nutrient.

AB - Although vitamin D3 is a natural product of a sunlight-mediated process in the skin, the secosteroid's biological function is dependent upon specific cytochrome P450 enzymes that mediate the parent vitamin's bioactivation and inactivation. Cytochrome P450C1 (CYP27B1) is the regulatory rate-limiting enzyme that directs the bioactivation process through introduction of a C-1 α hydroxyl group. The resultant 1,25-dihydroxyvitamin D3 (1,25D) is the biologically active secosteroid hormone that directs the multitude of vitamin D-dependent actions involved with calcium homeostasis, cellular differentiation and growth, and the immune response. The circulating and cellular level of 1,25D is regulated through a coordinated process involving the hormone's synthesis and degradation. Central to the degradation and turnover of 1,25D is the regulatory multi-catalytic cytochrome P450C24 (CYP24) enzyme that directs the introduction of C-24R groups onto targeted 25-hydroxy substrates. Discussed in this article is the action of the rat CYP24 to catalyze the side-chain oxidation and cleavage of 25-hydroxylated vitamin D metabolites. Expression and characterization of purified recombinant rat CYP24 is discussed in light of mutations directed at the enzyme's active site. © 2002 Wiley-Liss, Inc.

Salivary Pathogen Molecular Testing – we strongly encourage all or our clients to have a simple saliva molecular test (provided at our clinic) to determine definitively and quantitatively which periodontal pathogens are present in their infection .  Every case is different. This highly definitive test directs treatment therapy moving forward and provides valuable information about the decision to use adjunctive systemic antibiotics . This is considered “individualized periodontal medicine” since we are not guessing about virulent pathogen involvement, thus we can pinpoint the appropriate short term antibiotic for the infection.  Health history factors and medical lab test results are take into account before any definitive decisions are made for appropriate therapy moving forward.  We often involve the medical doctor (or specialist, such as a cardiologist) in the decision making process based on systemic health issues already present. For example, if a patient has a history of heart disease, atherosclerosis, or stroke, and the molecular pathogen test returns with high levels of certain pathogens known to contribute to vascular inflammation , we are going to be much more proactive in our multidisciplinary treatment approach.  This would mean more frequent pathogen testing and possibly a much more frequent supportive periodontal maintenance program. This also empowers the patient through education, if the patient is educated to understand the mouth-body connection, and how it can relate to serious systemic diseases, they can become more involved in their own co-therapy.

If vitamin D level in the blood is merely a biomarker, a consequence of good or bad health, then adding  vitamin D to the diet will not necessarily improve your health.  To really know whether vitamin D supplementation is beneficial, we need to look at interventional studies, where supplements are provided, and the outcomes are compared with those of control subjects who don’t get the supplement.  In fact the two above-cited studies on the effects of supplementation on bone fractures in older women, and prostrate cancer in older men are two such interventional studies.  And they showed that vitamin D supplementation was harmful in both cases.  And note that the positive Utah study I cited above–showing a correlation between low vitamin D levels and elevated incidence of cardiovascular disease and stroke–was an observational study, not an interventional one.  The men in that study with the higher vitamin D blood levels and lower incidence of heart disease were not given supplements.

Secosteroid function

secosteroid function

Salivary Pathogen Molecular Testing – we strongly encourage all or our clients to have a simple saliva molecular test (provided at our clinic) to determine definitively and quantitatively which periodontal pathogens are present in their infection .  Every case is different. This highly definitive test directs treatment therapy moving forward and provides valuable information about the decision to use adjunctive systemic antibiotics . This is considered “individualized periodontal medicine” since we are not guessing about virulent pathogen involvement, thus we can pinpoint the appropriate short term antibiotic for the infection.  Health history factors and medical lab test results are take into account before any definitive decisions are made for appropriate therapy moving forward.  We often involve the medical doctor (or specialist, such as a cardiologist) in the decision making process based on systemic health issues already present. For example, if a patient has a history of heart disease, atherosclerosis, or stroke, and the molecular pathogen test returns with high levels of certain pathogens known to contribute to vascular inflammation , we are going to be much more proactive in our multidisciplinary treatment approach.  This would mean more frequent pathogen testing and possibly a much more frequent supportive periodontal maintenance program. This also empowers the patient through education, if the patient is educated to understand the mouth-body connection, and how it can relate to serious systemic diseases, they can become more involved in their own co-therapy.

Media:

secosteroid functionsecosteroid functionsecosteroid functionsecosteroid function

http://buy-steroids.org