Oxypregnane steroidal glycoside

Hoodia is prepared from the stems and roots of the succlent plant Hoodia gordonii found in the Kalahari Desert and claimed to be used traditionally by Kalahari Bushmen to reduce their hunger and thirst during long hunts.  However, it may be more accurate to say that Hoodia is a food source and was used mostly to quench thirst.  Nevertheless, scientific studies in laboratory animals have shown that extracts of hoodia containing an oxypregnane steroidal glycoside have appetite suppressing activity.  The traditional use and subsequent laboratory findings led to the marketing of hoodia as a weight loss agent.  Dried extracts of stems and roots are used to make powders, capsules, chewable tablets and liquid preparations for making teas.  Hoodia is often combined with other purported weight loss herbs such as green tea and chromium picolinate.  To date, there have been no prospective controlled trials demonstrating an effect of hoodia on food intake or weight management in humans.  In uncontrolled studies, use of hoodia has been reported to have no adverse side effects.

P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after administration of a single dose of enriched methanolic extract of HOODIA GORDONII (equivalent to a dose of 25 mg of P57/kg) by oral gavage or a single dose of purified P57 (25 mg/kg) intravenously. The level of P57 in plasma and tissues (brain, liver, kidney, and intestine) was determined by UPLC-MS. After oral administration of HOODIA extract, the peak plasma level of P57 was achieved in  h. Upon intravenous administration, the plasma clearance rate of P57 was  L/h/kg. P57 was rapidly distributed and eliminated from the tissues within 4 hours. The level of tissue distribution was highest in the kidney followed by liver and brain. Upon oral administration, P57 was not detected in the brain and a very low concentration was seen in the intestine, kidney, and liver. Tissue/plasma ratio was for brain, for liver, and for kidney with IV route and for intestine, for liver, and for kidney with oral route. The half-life of the elimination phase was similar with both routes. The oral bioavailability was  % and the half-life of the absorption phase was  h. In conclusion, P57 showed moderate bioavailability and was eliminated rapidly.

This is from my experience with Plexus. I took it on and off for a couple of months, but last month I decided to stick with it. I got my bag of Plexus Slim shakes at the start of August 2014. My mom used to be an ambassador for them but since she’s not a salesman she dropped out, so that is how I heard of it. Originally I ordered some to help her out. Anyway, come August 2014, I started taking it and I do one packet a day first thing in the morning before I eat anything and wait 30 mins before I eat anything after taking the shake. Anyway, about a week into it, I started getting severe diarrhea, and serious stomach aches and cramps and gas, which I figured it was the way it works, it gets rid of the nasty stuff in my body. Well, after a week of severe diarrhea, I continued on having it, but this time with blood. I was going to the bathroom at least 6 – 8 times a day. It is now August 21st, 2014 and I stopped taking Plexus slim Saturday August 16 and have not had it since and I am still dealing with severe diarrhea and blood. The stomach cramps have stopped, but now I’m starting to get a little worried. I’ve been to the bathroom at least 6 times today with nothing but serious diarrhea and some of it with blood. If it doesnt stop, I’m going to have to go to the doctor. So if you’re planning on taking this, please be careful because as you can see, it has it’s side effects. It did help me lose weight, but I think I can find a better product to help me lose weight without the severe diarrhea.

My 18 year old daughter and I have both started on Plexus. (With our PCP’s approval). I have a cousin who is an ambassador. She had approached me during the summer but I wasn’t about to sign up. I just don’t get on the diet band wagons. I would read her posts or get things in my newsfeed. I would ignore them and move on – until one day another cousin had posted how Plexus had helped with her thryoid. It caught my attention and my cousin sent my daughter a 7 day trial pack. I started looking more closely at the results people were achieving. I’m skeptical of anything that has fast or extreme results. I’ve been on the Slim and Accelerator for about a month – I’ve lost some inches -not pounds. But, I did not sign up to lose weight – I had started having more frequent sugar drops this past year and wanted to do the diabetic meal plan and plexus to balance my glucose levels. I’m feeling better than I have in years. My energy level is perfect. I’m not bouncing off the wall – but I feel better/happier even. I’m going to drop the accelerator and switch to the BioCleanse and ProBio5. I read some of the negative reviews and I hate that it didn’t work for you. My daughter was pre-diabetic and after a month on Plexus – her A1C dropped to within normal range. We’re both pleased with the products. I have 4 grown kids and they are pre-dispositioned for diabetes and I am at risk as well.. $109 a month is a small price to pay if this helps stave off diabetes. Eye problems, circulatory problems, kidney problems can be problematic for diabetics. Diet and exercise are key. But the product has delivered what it said it would do. I think the primary negative posts were about not losing weight for the most part The product was made for Type II diabetics to help balance their levels. I’ve seen many posts from those who have been on Plexus for a year and two years out and some have acheived “wow” results, others may be only down a couple of dress sizes. I’m not so much interested in losing weight (even though I need too desperately). I am more interested in better health. We’ll continue with Plexus. If we experience any issues down the road, we will talk it over with our doctor.

Oxypregnane steroidal glycoside

oxypregnane steroidal glycoside

My 18 year old daughter and I have both started on Plexus. (With our PCP’s approval). I have a cousin who is an ambassador. She had approached me during the summer but I wasn’t about to sign up. I just don’t get on the diet band wagons. I would read her posts or get things in my newsfeed. I would ignore them and move on – until one day another cousin had posted how Plexus had helped with her thryoid. It caught my attention and my cousin sent my daughter a 7 day trial pack. I started looking more closely at the results people were achieving. I’m skeptical of anything that has fast or extreme results. I’ve been on the Slim and Accelerator for about a month – I’ve lost some inches -not pounds. But, I did not sign up to lose weight – I had started having more frequent sugar drops this past year and wanted to do the diabetic meal plan and plexus to balance my glucose levels. I’m feeling better than I have in years. My energy level is perfect. I’m not bouncing off the wall – but I feel better/happier even. I’m going to drop the accelerator and switch to the BioCleanse and ProBio5. I read some of the negative reviews and I hate that it didn’t work for you. My daughter was pre-diabetic and after a month on Plexus – her A1C dropped to within normal range. We’re both pleased with the products. I have 4 grown kids and they are pre-dispositioned for diabetes and I am at risk as well.. $109 a month is a small price to pay if this helps stave off diabetes. Eye problems, circulatory problems, kidney problems can be problematic for diabetics. Diet and exercise are key. But the product has delivered what it said it would do. I think the primary negative posts were about not losing weight for the most part The product was made for Type II diabetics to help balance their levels. I’ve seen many posts from those who have been on Plexus for a year and two years out and some have acheived “wow” results, others may be only down a couple of dress sizes. I’m not so much interested in losing weight (even though I need too desperately). I am more interested in better health. We’ll continue with Plexus. If we experience any issues down the road, we will talk it over with our doctor.

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