Oral equivalent to unasyn

The mean change in length of stay was not significantly ( P = .05) reduced in studies of early switch and early discharge (- d; 95% CI, - to d). However, when the 2 studies in which the recommended length of stay was longer than the control length of stay were excluded from the analysis, the mean change in length of stay was reduced by 3 days (- d; 95% CI, - to - d). Studies did not reveal significant differences in clinical outcomes between the intervention and control groups. Rhew and colleagues concluded that criteria for early switching from parenteral to oral antibiotics vary considerably for patients with CAP. Early-switch and early-discharge strategies may significantly and safely reduce the mean length of stay when the recommended length of stay is shorter than the actual length of stay. [ 20 ]

Data from a controlled clinical trial conducted in pediatric patients provided evidence supporting the safety and efficacy of UNASYN for the treatment of skin and skin structure infections. Of 99 pediatric patients evaluable for clinical efficacy, 60 patients received a regimen containing intravenous UNASYN, and 39 patients received a regimen containing intravenous cefuroxime . This trial demonstrated similar outcomes (assessed at an appropriate interval after discontinuation of all antimicrobial therapy) for UNASYN- and cefuroxime-treated patients:

Although patients with acute pyelonephritis traditionally have been hospitalized and treated with intravenous antibiotics, outpatient oral therapy is successful in 90 percent of selected patients with uncomplicated acute pyelonephritis who can tolerate oral intake, will be compliant with the treatment regimen, will return for early follow-up, and have adequate social support 27 , 28 ( Figure 2 ) . Patients with complicated acute pyelonephritis who are more ill or have not responded to outpatient therapy should be hospitalized. Using specific hospitalization criteria ( Table 4 ) , 1 up to 70 percent of patients can be selected for outpatient management. Another option is initial therapy with parenteral antibiotics in an inpatient observation unit, followed by oral therapy as an outpatient. 26 , 29

When prochlorperazine is used with cancer chemotherapeutic drugs, vomiting as a sign of the toxicity of these agents may be obscured by the antiemetic effect of prochlorperazine. Because hypotension may occur, large doses and parenteral administration should be used cautiously in patients with impaired cardiovascular systems. If hypotension occurs after parenteral or oral dosing, place patient in head-low position with legs raised. If a vasoconstrictor is required, norepinephrine bitartrate and phenylephrine hydrochloride are suitable. Other pressor agents, including epinephrine , should not be used because they may cause a paradoxical further lowering of blood pressure. Aspiration of vomitus has occurred in a few post-surgical patients who have received prochlorperazine as an antiemetic. Although no causal relationship has been established, this possibility should be borne in mind during surgical aftercare.

Oral equivalent to unasyn

oral equivalent to unasyn

When prochlorperazine is used with cancer chemotherapeutic drugs, vomiting as a sign of the toxicity of these agents may be obscured by the antiemetic effect of prochlorperazine. Because hypotension may occur, large doses and parenteral administration should be used cautiously in patients with impaired cardiovascular systems. If hypotension occurs after parenteral or oral dosing, place patient in head-low position with legs raised. If a vasoconstrictor is required, norepinephrine bitartrate and phenylephrine hydrochloride are suitable. Other pressor agents, including epinephrine , should not be used because they may cause a paradoxical further lowering of blood pressure. Aspiration of vomitus has occurred in a few post-surgical patients who have received prochlorperazine as an antiemetic. Although no causal relationship has been established, this possibility should be borne in mind during surgical aftercare.

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