Formulations of topical diclofenac, ibuprofen, ketoprofen, piroxicam, and indomethacin demonstrated significantly higher rates of clinical success (more participants with at least 50% pain relief) than matching topical placebo (moderate or high quality data ). Benzydamine did not. Three drug and formulation combinations had NNTs for clinical success below 4. For diclofenac, the Emulgel® formulation had the lowest NNT of (95% CI to ) in two studies using at least 50% pain intensity reduction as the outcome . Diclofenac plasters other than Flector® also had a low NNT of ( to ) based on good or excellent responses in some studies. Ketoprofen gel had an NNT of ( to ), from five studies in the 1980s, some with less well defined outcomes. Ibuprofen gel had an NNT of ( to ) from two studies with outcomes of marked improvement or complete remission. All other drug and formulation combinations had NNT values above 4, indicating lesser efficacy .
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Be carefull if you select a pian specialist, i was referd to one by my pcp, the guy walked in looked at me and said whats the problem, so i showed him my leg and the other areas where the scleroderma(generilzed morphiea) was and how long i have had it. he said quote; i seen this before and when you are lying in the hospital with the soars all over you and dying i will give you pain meds to put you out of the misery,if i poke the spot that hurts and you dont scream and want to run out of here then you are in no pain; didnt even give me a exam. i did report him to medicare and thiking of reporting him to the medical board.