Neurosteroids review

Unlike benzodiazepines, etifoxine appears to produce its anxiolytic effects by activating β2 and β3 subunit containing channels of the GABA A receptor complex (a different binding site than benzodiazepines), and by stimulating the production of GABA(A) active neurosteroids that act in conjunction with etifoxine's direct effects. [9] This difference in binding means that etifoxine can be used alongside benzodiazepines to potentiate their effects without competing for binding sites; [10] however, it also means that the effects of etifoxine are not reversed by the benzodiazepine antagonist flumazenil . [11]

Neurosteroids review

neurosteroids review

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