The Epstein Barr Virus is what leads to mononucleosis and it can be found throughout the world. Although this virus can infect just about anyone, mono is more common in children, teenagers, adolescents and younger adults. Studies indicate that in the United States, around 95% of the adults between the ages of 35 and 40 have already developed antibodies against EBV. This means that most of us have been infected by the virus at some time or the other. It is also important to realize that once the virus enters your body, it will always stay there. However, it remains dormant for a majority of the time, but can get active once in a while. When it is active, it can be transmitted from one person to the other, causing mono to spread.
Paracetamol (acetaminophen) and NSAIDs , such as ibuprofen , may be used to reduce fever and pain. Prednisone , a corticosteroid , while used to try to reduce throat pain or enlarged tonsils , remains controversial due to the lack of evidence that it is effective and the potential for side effects.   Intravenous corticosteroids , usually hydrocortisone or dexamethasone , are not recommended for routine use but may be useful if there is a risk of airway obstruction, a very low platelet count , or hemolytic anemia .