Because BT-474 cells express both ERα and HER2 ( Lazaro et al. 2013 ), they represent a suitable cell model to explore the interactions between ERα and HER2 signaling pathways. BT-474 cells were treated with MP, EP, PP, and BP, all of which are commonly present in cosmetics and in personal-care products, in the absence and presence of HRG. Of the parabens listed above, PP and BP were the most effective at increasing c-Myc mRNA expression in the absence of HRG ( Figure 1A ). HRG alone produced an approximately 3-fold increase in c-Myc mRNA expression, but a synergistic increase that was greater than additive was observed with PP and BP ( Figure 1A ). BP was the most effective stimulator of c-Myc mRNA expression in the absence and presence of HRG and was selected for further studies. The maximal increase of c-Myc expression by BP was observed at a concentration of 10 μM ( Figure 1B ). The synergistic effect of HRG was observed when BT-474 cells were treated with BP for 1 hr ( Figure 1C ). These results indicate that HRG decreased the dose required for the BP-mediated increase in c-Myc mRNA expression and enhanced the magnitude of the BP response.
Due to the need for a strong PCT and Aromasin carrying extremely strong natural testosterone stimulating properties, this makes it very appealing for this purpose. Due to the slight androgenic nature and moderately decent promotion of IGF-1 this makes it even more appealing. However, we must consider the primary purpose of Aromasin, which is as an anti-estrogen. High levels of estrogen can be problematic, but the hormone is still necessary to our body’s health. It is important in maintaining a proper immune system, as well as in the maintenance of healthy cholesterol levels. Then consider the PCT, which in part is primarily designed to stimulate natural testosterone production, but the overall primary point is to normalize the body. We cannot normalize with low estrogen levels. For a proper PCT that not only stimulates testosterone production but promotes overall normalization, SERM’s should always be your first choice.
The new study examined recent stretch marks and found that they had a higher density of hormone receptors than normal skin, and estrogen appeared to be the most concentrated. Since estrogen is involved in skin healing, that could represent the body’s attempt to heal the injured skin tissue. From the standpoint of steroid users, the greater number of estrogen receptors in stretch marks could also represent a defense against the high level of androgens, which interfere with skin healing. That latter part, however, is strictly speculation. What is known is that stretch marks have a higher density of hormone receptors than normal skin.